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Due to the lack of GH and GHR on the regulation of mitophagy, we proposed that these discrepant results of GH and GHR on mitochondrial function may be explained by the coordinated regulation mechanism between mitochondrial biogenesis and mitophagy to meet different physiological conditions in vivo and in vitro

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For BPC-157 specifically, the FDA reported limited and short human studies, a lack of adequate studies for several commonly used routes of administration, potential immunogenicity concerns, possible liver and clotting signals in animal studies, and three adverse-event reports, while noting that a cause could not be established